Emory University    Department of Cell Biology    Imaging Core    Whitehead Biomedical Research Building
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Selected Publications
2009-2010
Sasaki Y, Welshhans K, Wen Z, Yao J, Xu M, Goshima Y, Zheng JQ, Bassell GJ. Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local beta-Actin Synthesis and Growth Cone Turning. J Neurosci. 2010 Jul 14;30:9349-58. Fallini C, Bassell GJ, Rossoll W. High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function. Mol Neurodegener. 2010 Apr 21;5:17 Li C, Bassell GJ, Sasaki Y. Fragile X Mental Retardation Protein is Involved in Protein Synthesis-Dependent Collapse of Growth Cones Induced by Semaphorin-3A. Front Neural Circuits. 2009;3:11. Santangelo PJ, Lifland AW, Curt P, Sasaki Y, Bassell GJ, Lindquist ME, Crowe JE Jr. Single molecule-sensitive probes for imaging RNA in live cells. Nat Methods. 2009 May;6(5):347-9. Epub 2009 Apr 6. Rossoll W, Bassell GJ. Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes.  Results Probl Cell Differ. 2009;48:289-326. Muddashetty R, Bassell GJ. A boost in microRNAs shapes up the neuron. EMBO J. 2009 Mar 18;28(6):617-8.
2007-2008
Bassell GJ and Warren ST. Fragile x syndrome: Loss of local mRNA regulation shaping synaptic development and function. Neuron, 2008, 60(2):201-214. PubMed  / PDF Narayan U, Nalavadi V, Nakamoto M, Thomas G, Ceman S, Bassell GJ and Warren ST. S6K1 phosphorylates and regulates FMRP with the neuronal protein synthesis dependent mTOR signaling cascade. JBC, 2008, 283(27):18478-18482. PubMed  / PDF Dictenberg JB, Antar LN, Li C, Singer RH and Bassell GJ. Deficient activity-dependent mRNA transport in a mouse model of Fragile X Syndrome. Developmental Cell, 2008, 14(6);926-939. PubMed  / PDF Oprea GE, McWhorter ML, Rossoll W, Muller S, Krawczak M, Bassell GJ, Beattie CE and Wirth B. Plastin-3 is a protective modifier of SMN1 in spinal muscular atrophy. Science, 2008, 320(5875):524-227. PubMed  / PDF Bassell GJ and Gross C. Reducing glutamate signaling pays off in fragile X. Nature Medicine, 2008, 14(3):249-250. PubMed  / PDF Wang H, Dictenberg J, Ku L, Bassell GJ and Feng Y. Dynamic association of FMRP as an mRNP between microtubules and translating polyribosomes. Molecular Biology of the Cell, 2008, 19(1):105-114. PubMed  / PDF Narayanan U, Nalavadi V, Nakamoto M, Pallas D, Ceman C, Bassell GJ and Warren ST. mGluR-dependent FMRP dephosphorylation in dendrites reveals an early and dynamic phase of neuronal translation. Journal of Neuroscience, 2007, 27(52):14349-14357. PubMed  / PDF Willis DE, Sasaki Y, Mesngon M, Merianda TT, Williams GG, Kendall M, Smith DS, Bassell GJ and Twiss JL. Extracellular stimuli specifically regulate localized levels if individual neuronal mRNAs. Journal of Cell Biology, 2007, 178(6):965-980. PubMed  / PDF Nakamoto M, Nalavadi V, Epstein MP, Narayanan Y, Bassell GJ and Warren ST. Fragile X Mental Retardation protein deficiency leads to spontaneous mGluR5-dependent internalization of AMPA receptors. PNAS, 2007, 104(39):15537-15542. PubMed  / PDF Muddashetty R, Kelic S, Gross C, Xu M and Bassell GJ. Dysregulated mGluR-dependent translation of AMPA receptor and PSD-95 mRNAs in a mouse model of fragile x syndrome. Journal of Neuroscience, 2007, 27(20):5338-5348. PubMed  / PDF
2005-2006
Carrel TL, McWhorter ML, Workman E, Zhang HL, Lorson C, Bassell, G.J., Burghes AH and Beattie CE. SMN function in motor axons does not require efficient oligomerization of Sm protein binding. Journal of Neuroscience, 2006, 26(43):11014-11022. PubMed  /  PDF Kiebler M and Bassell, G.J.. Neuronal RNA granules: movers and makers. Neuron, 2006, 51(6):685-690. PubMed  /  PDF Yao J, Sasaki Y, Wen Z, Bassell, G.J. and Zheng JQ. An essential role for β-actin mRNA localization and translation in Ca-dependent growth cone guidance. Nature Neuroscience, 2006, 9(10):1265-1273. PubMed  /  PDF Zhang HL, Xing L, Rossoll WM Wichterle H, Singer RH and Bassell, G.J.. Survival of Motor Neuron protein (SMN) forms a multiprotein complex with Gemins and traffics to neuronal processes and growth cones. Journal of Neuroscience, 2006, 26(33): 8622-8632. PubMed  /  PDF Grooms SY, Noh KM, Regis R, Bryan MK, Bassell, G.J., Carroll RC and Zukin RS. Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons. Journal of Neuroscience, 2006, 26(32); 8339-8351. PubMed  /  PDF Antar LN, Li C, Zhang H, Carroll R and Bassell, G.J.. Local functions for FMRP in axon growth cone motility and activity dependent regulation of filopodia and spine synapses. Molecular and Cellular Neuroscience, 2006, 32:37-48. PubMed  /  PDF Bassell, G.J. and Twiss JL. RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control of neuronal function. EMBO Reports, 2006; 7(1):31-35. PubMed  /  PDF H¨ttelmaier S, Zenklusen D, Lederer M, Lorenz M, Dictenberg JB, Meng XH, Bassell, G.J., Condeelis J and Singer RH. Spatial regulation of β-actin translation by ZBP1. Nature, 2005;438:512-515. PubMed  /  PDF Le TT, Lan T, Pham U, Monani R, Coovert DD, Matthew ER, Gavrilin TO, Zhang HL, Bassell, G.J., Burghes AH. Expression of SMNd7, the major product of the centromeric survival motor neuron gene (SMN2), extends survival in mice with spinal muscular atrophy. Human Molecular Genetics, 2005; 14:845-857. PubMed  /  PDF Antar LN, Dictenberg JB, Bassell, G.J.. Requirement of microtubules for metabotropic glutamate receptor stimulated transport of FMRP in dendrites. Genes, Brain and Behavior, 2005; 4:350-359. PubMed  /  PDF
2003-2004
Bassell, G.J. and Kelic, S. (2004) Binding proteins for mRNA localization, local translation and their dysfunction in genetic neurological disease. Current Opinion in Neurobiology, 14:574-581. PubMed  /  PDF Smith, C.L., Afroz, R., Bassell,G.J., Furneaux,H.M., Perrone-Bizzozero,N.I. and Burry, R.W. GAP-43 mRNA in growth cones is associated with HuD and ribosomes. Journal of Neurobiology, 2004; 61: 222-235. PubMed  /  PDF Antar, L.N., Afroz, R., Dictenberg, J.B., Carroll, R.C. and Bassell, G.J. Metabotropic glutamate receptor activation regulates Fragile X Mental Retardation Protein and Fmr1 mRNA localization differentially in dendrites and at synapses. Journal of Neuroscience, 2004; 24:2468-2655. PubMed  /  PDF Eom, T., Antar, L.M., Singer, R.H. and Bassell, G.J. Localization of a β-actin mRNP complex with zipcode binding protein modulates the density of dendritic filopodia and filopodial-synapses. Journal of Neuroscience, 2003;23:10433-10444. PubMed  /  PDF Zhang, H.L., Pan, F., Hong, B., Shenoy, S.M., Singer, R.H. and Bassell, G.J. Active transport of the Survival of Motor Neuron Protein (SMN) and the role of exon-7 in cytoplasmic localization. Journal of Neuroscience, 2003;23:6627-6637. PubMed  /  PDF Dhanrajan, T.M., Oleynikov,Y., Kelic,S., Shenoy,S.M., Hartley,A., Stanton,P.K., Singer,R.H.and Bassell, G.J. Activity-dependent trafficking and dynamic localization of ZBP1 and β-actin mRNA in dendrites and spines of hippocampal neurons. Journal of Neuroscience, 2003;23:3251-3261. PubMed  /  PDF Antar,L.N. and Bassell, G.J. Sunrise at the Synapse: The FMRP mRNP Shaping the Synaptic Interface. Neuron, 2003;37:555-558. PubMed  /  PDF
1994-2002
Gu, W., Feng, P., Zhang, H.L., Bassell, G.J., and Singer, R.H. A predominantly nuclear protein affecting cytoplasmic localization of b-actin mRNA in fibroblasts and neurons. Journal of Cell Biology, 2002; 156:41-51. PubMed  /  PDF Zhang, H.L., Eom, T., Oleynikov, Y., Shenoy, S.M., Liebelt, D.A., Dictenberg, J.B., Singer, R.H. and Bassell, G.J., Neurotrophin induced transport of b-actin mRNA with Zipcode Binding Protein in neuronal processes increases b-actin levels and stimulates growth cone motility. Neuron, 2001; 31:261-275. PubMed  /  PDF Zhang, H.L., Singer, R.H. and Bassell, G.J., Neurotrophin signaling of b-actin mRNA and protein localization within growth cones. Journal of Cell Biology. 1999; 147:59-70. PubMed  /  PDF Bassell, G.J., Zhang, H.L., Byrd, A.L., Femino, A.M., Singer, R.H.,. Taneja, K.L., Lifshitz, L.M., Herman, I.M., and Kosik, K.S. Sorting of b-actin mRNA and protein to neurites and growth cones in culture. Journal of Neuroscience. 1998;18:251-265. PubMed  /  PDF Knowles, R.B., Sabry, J.H., Martonne, M.E., Deerinck, T.J., Ellisman M.H.,Bassell, G.J., and Kosik, K.S. Translocation of RNA granules in living neurons. Journal of Neuroscience. 1996; 16(24):7812-7820. PubMed  /  PDF Somasundaran, M., Zapp, M. L., Beattie, L. K., Lizhen, P., Byron, K. S., Bassell, G.J., Sullivan, J. L., and Singer, R. H. Localization of HIV RNA in mitochondria of infected cells; potential role in cytopathogenicity. Journal of Cell Biology. 1994; 126, 1353-1360. PubMed  /  PDF Bassell, G.J., Singer, R.H. and Kosik, K.S. Association of poly(A) mRNA with microtubules in cultured neurons. Neuron. 1994; 12: 571-582. PubMed Bassell, G.J., Powers, C.M., Taneja, K.L. and Singer, R.H. Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections. Journal of Cell Biology. 1994;126:863-876. PubMed  /  PDF
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